CNRS Research Director
Director of TNA research group
President of the French Medicinal Chemistry Society
Director of the GDR RNA Network
Chemistry Europe Fellow
Institute of Chemistry of Nice (ICN)
UMR7272 Université Côte d'Azur - CNRS
28 avenue Valrose 06100 Nice FRANCE
ContactCurriculum vitae
- Associate Editor for RSC Medicinal Chemistry (Royal Society of Chemistry)
- Member of the Editorial Advisory Board of Journal of Medicinal Chemistry (American Chemical Society, ACS)
- Member of the Scientific Advisory Board of ChemMedChem (Wiley)
- PhD in Molecular Biochemistry from the National Museum of Natural History (Paris, France)
- MS in Pharmaceutical Chemistry from the Faculty of Pharmacy of the University of Bologna (Italy)
Awards and Honours
- Alexandre Joël Award from Fondation ARC (2004)
- Michel Delalande Award from the French Pharmacy Academy (2007)
- Chemistry Europe Fellow Award (2023)
- Sanofi iDEA-TECH Europe Award (2024)
- Université Côte d'Azur Excellence Award (2024)
- Grand Prix SCF-PACA Award (2025)
- Université Côte d'Azur Excellence Award (2025)
Key Publications
Panosetti, M., Vecchio, D., Maucort, C., Mongiardini, V., Di Giorgio, A., Grimaldi, B., Duca, M. Reversing the Hypoxic Adaptive Response in Breast Cancer Cells through Small-Molecule Inhibition of Oncogenic MicroRNA-210. J. Med. Chem. 2026 69, 2814.
Martin C, Panosetti M, Tesini E, Azoulay S, Bugaut A, Sinou V, Patino N, Di Giorgio A, Darfeuille F, Duca M. Synthetic RNA ligands as activators of type I toxin-antitoxin systems: a novel antimicrobial strategy targeting Helicobacter pylori. Chem. Sci. 2025 16, 13249.
Pernak M, Fleurisson C, Delorme C, Moumné R, Benedetti E, Micouin L, Azoulay S, Foricher Y, Duca M. Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA. ACS Chem. Biol. 2025 20, 1068.
Kovachka S, Panosetti M, Grimaldi B, Azoulay S, Di Giorgio A, Duca M. Small molecule approaches to targeting RNA. Nature Rev. Chem. 2024 8, 120.
Vo D.D., Staedel C., Zehnacker L., Benhida R., Darfeuille F., Duca M.* Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules. ACS Chem. Biol. 2014 9, 711.
Selected Media
- Presentation of 2020 Nobel Prize in Chemistry - Nobel Day Nice
- Chemistry World Interview (Royal Society of Chemistry) about RNA targeting with small molecules
- Interview for Chemical & Engineering News (C&EN) about the use of RNA ligands against SARS-CoV-2
- Interview for Chemistry Views (Chemistry Europe) of our ChemPlusChem 2020 article