Molécules Bioactives
CNRS Research Director
Director of TNA research group
Institute of Chemistry of Nice (ICN)
UMR7272 Université Côte d'Azur - CNRS
28 avenue Valrose 06100 Nice FRANCE
ContactCurriculum vitae
- Vice-President of the French Medicinal Chemistry Society (SCT)
- Associate Editor for RSC Medicinal Chemistry (Royal Society of Chemistry)
- Chair of the Chemical Biology Initiative for the European Federation of Medicinal Chemistry
- Chair of the Scientific Committee of the French Medicinal Chemistry Society (SCT)
- Member of the Editorial Advisory Board of Journal of Medicinal Chemistry (American Chemical Society, ACS)
- Member of the Scientific Advisory Board of ChemMedChem (Wiley)
- Member of the Communication Committee of the International Chemical Biology Society (ICBS)
- PhD in Molecular Biochemistry from the National Museum of Natural History (Paris, France)
- MS in Pharmaceutical Chemistry from the Faculty of Pharmacy of the University of Bologna (Italy)
Awards and Honours
- Alexandre Joël Award from Fondation ARC (2004)
- Michel Delalande Award from the French Pharmacy Academy (2007)
Key Publications
Tran, T.P.A., Poulet, S., Pernak, M., Rayar, A., Azoulay, S., Di Giorgio A., Duca, M. Development of 2-deoxystreptamine-nucleobase conjugates for the inhibition of oncogenic miRNAs production. RSC Med. Chem. 2022 13, 311.
Maucort, C., Vo, D.D., Aouad, S., Charrat, C., Azoulay, S., Di Giorgio, A., Duca, M. Design and implementation of synthetic RNA binders for the inhibition of miR-21 biogenesis. ACS Med. Chem. Lett. 2021 12, 899.
Joly J.P., Gaysinski M., Zara L., Duca M.*, Benhida, R. Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA. Chem. Commun. 2019 27, 10432
Staedel, C., Tran, T.P.A., Giraud, J., Darfeuille, F., Di Giorgio, A., Tourasse, N.J., Salin, F., Uriac, P., Duca, M.* Modulation of oncogenic miRNA biogenesis using functionalized polyamines. Scientific Reports 2018 8, 1667
Vo D.D., Staedel C., Zehnacker L., Benhida R., Darfeuille F., Duca M.* Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules. ACS Chem. Biol. 2014 9, 711.
Selected Media
- Presentation of 2020 Nobel Prize in Chemistry - Nobel Day Nice
- Chemistry World Interview (Royal Society of Chemistry) about RNA targeting with small molecules
- Interview for Chemical & Engineering News (C&EN) about the use of RNA ligands against SARS-CoV-2
- Présentation sur Chemistry Views (Chemistry Europe) of our ChemPlusChem 2020 article