Maria Duca

CNRS Research Director

Associate Editor for RSC Medicinal Chemistry (Royal Society of Chemistry)
Member of the Chemical Biology Initiative for the European Federation of Medicinal Chemistry
Member of the Editorial Advisory Board of Journal of Medicinal Chemistry (American Chemical Society, ACS)
Member of the Scientific Advisory Board of ChemMedChem (Wiley)
PhD in Molecular Biochemistry from the National Museum of Natural History (Paris, France)
MS in Pharmaceutical Chemistry from the Faculty of Pharmacy of the University of Bologna (Italy)

Scheheoleva I., Fernandez-Remacha, D., Estrada-Tejedor, R., Duca, M., Michelet, V. De novo design of pre-miR-21 maturation inhibitors: synthesis and activity assessment. Chem. Eur. J. 2023 doi.org/10.1002/chem.202300825

Tran, T.P.A., Poulet, S., Pernak, M., Rayar, A., Azoulay, S., Di Giorgio A., Duca, M. Development of 2-deoxystreptamine-nucleobase conjugates for the inhibition of oncogenic miRNAs production. RSC Med. Chem. 2022 13, 311.

Maucort, C., Vo, D.D., Aouad, S., Charrat, C., Azoulay, S., Di Giorgio, A., Duca, M. Design and implementation of synthetic RNA binders for the inhibition of miR-21 biogenesis. ACS Med. Chem. Lett. 2021 12, 899.

Staedel, C., Tran, T.P.A., Giraud, J., Darfeuille, F., Di Giorgio, A., Tourasse, N.J., Salin, F., Uriac, P., Duca, M.* Modulation of oncogenic miRNA biogenesis using functionalized polyamines. Scientific Reports 2018 8, 1667

Vo D.D., Staedel C., Zehnacker L., Benhida R., Darfeuille F., Duca M.* Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules. ACS Chem. Biol. 2014 9, 711.

Presentation of 2020 Nobel Prize in Chemistry - Nobel Day Nice
Chemistry World Interview (Royal Society of Chemistry) about RNA targeting with small molecules
Interview for Chemical & Engineering News (C&EN) about the use of RNA ligands against SARS-CoV-2
Interview for Chemistry Views (Chemistry Europe) of our ChemPlusChem 2020 article